VCAM-1预测不良预后并调节胃癌的免疫透:基于TCGA的生物信息学研究
Cheng Wu1,2, Yungeng Liu1,2, Chuanyuan Liu1,2
1Department of Gastrointestinal and Hernia Surgery, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou, China.
Frontiers in genetics
|September 10, 2025
概括
血管细胞粘附分子-1 (VCAM-1) 在胃癌中被上调,预测存活率较低,并影响瘤免疫微环境. VCAM-1可以通过调节免疫细胞透来优化胃癌免疫疗法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 胃癌 (GC) 是癌症死亡的主要原因,预测免疫疗法耐药性的生物标志物有限.
- 血管细胞粘附分子-1 (VCAM-1) 参与瘤进展,但其在GC中的预后和免疫调节作用尚不清楚.
研究的目的:
- 研究VCAM-1表达在胃癌中的临床相关性和预后价值.
- 探索VCAM-1与GC中的瘤免疫微环境之间的关联.
主要方法:
- 来自癌症基因组图谱的RNA测序数据的分析,用于GC中的VCAM-1表达.
- 使用差异基因分析,基因组丰富分析 (GSEA) 和单样GSEA.
- 使用考克斯回归,ROC分析和来自人类蛋白质图谱数据库的免疫组织化学的验证结果.
主要成果:
- 在GC组织中,VCAM-1表达显著上调,与先进的T和N阶段以及较差的整体存活率相关.
- 根据GSEA的指示,VCAM-1与免疫通路 (如17-interleukin信号传递) 有关.
- 通过免疫组织化学证实,VCAM-1与Th1,细胞毒性和CD8+T细胞比例正相关,与Th17细胞相反.
结论:
- 在GC中,VCAM-1作为一种新的预后生物标志物,驱动一种免疫抑制瘤微环境.
- VCAM-1的双重免疫调节功能表明它有可能优化GC免疫疗法策略.
更多相关视频
10:28Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
11.5K
12:14CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells
Published on: June 2, 2022
3.0K
相关概念视频
02:07Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
01:21Cancer Survival Analysis
650
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
650
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
9.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.4K