在年轻患者接受乳腺癌治疗后怀孕
Young-Jin Lee1, Tae-Kyung Yoo1, Sae Byul Lee1
1Department of Surgery, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Republic of Korea.
Frontiers in oncology
|September 10, 2025
概括
乳腺癌 (BC) 治疗后怀孕是可能的,诸如年龄和以前的孩子等因素会影响结果. 对于接受BC治疗的生育年龄妇女来说,生育保护咨询至关重要.
科学领域:
- 在瘤学瘤学.
- 生殖医学 生殖医学
- 临床研究 临床研究
背景情况:
- 乳腺癌治疗可能会对年轻女性的生育能力产生负面影响.
- 关于乳腺癌治疗后怀孕结果的现实世界数据有限.
- 这些数据对于指导治疗决策和患者咨询至关重要.
研究的目的:
- 为了提供全面的真实世界的数据,乳腺癌治疗后的怀孕.
- 为了确定与后续怀孕相关的因素.
- 为了评估怀孕和乳腺癌幸存者怀孕的瘤结果.
主要方法:
- 对995名经期前妇女 (18-40岁) 进行了回顾性队列研究,她们患有0-III期乳腺癌.
- 数据来自韩国单一的三级医疗中心 (2010年12月 - 2020年9月).
- 主要结局包括怀孕率,受孕时间,怀孕结果和瘤结果.
主要成果:
- 在995名患者中,有115名患者 (11.6%) 在乳腺癌诊断后怀孕.
- 怀孕率因激素受体状况和先前的怀孕史而异.
- 在那些怀孕的人中,46.1%停止了内分泌疗法 (ET);在ET停止后试图怀孕的69.7%怀孕了.
- 在停止ET后怀孕的患者中,癌症复发发生在7.5%的患者中.
结论:
- 对所有生育年龄的乳腺癌患者来说,保育辅导是必不可少的.
- 了解化疗和ET对怀孕的影响对于管理患者至关重要.
- 现实世界的数据支持乳腺癌幸存者希望未来怀孕的知情决策.
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