MIND饮食得分及其与代谢功能障碍相关的脂肪性肝病及其肠道微生物群概况的关联:一个横截面研究
Shengbo Yang1, Litao Zhang1, Mingli Hu1
1Hepatobiliary Pancreatic Spleen Surgery, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, Guizhou Province, China.
Frontiers in nutrition
|September 10, 2025
概括
地中海-DASH干预神经退行性延迟 (MIND) 饮食与代谢功能障碍相关的脂肪性肝病 (MASLD) 的成年人肝脏健康状况改善有关. 更高的粘附性改善肝功能,减少炎症,并促进更健康的肠道微生物群.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 微生物组研究 微生物组研究
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- 饮食模式和肠道失调是影响MASLD进展的关键因素.
- 富含抗炎化合物的MIND饮食显示出缓解MASLD的潜力.
研究的目的:
- 调查坚持MIND饮食与MASLD严重程度之间的关联.
- 评估MIND饮食对肝硬化,纤维化,胰岛素抵抗和炎症的影响.
- 探索MASLD患者的MIND饮食坚持和肠道微生物群组成之间的关系.
主要方法:
- 在450名已确认患有MASLD的成年人中进行了横截面研究.
- 使用经过验证的食物频率问卷 (FFQ) 评估MIND饮食的坚持.
- 通过生物化学标记物和16S rRNA测序,评估肝脏肥胖症,纤维化,胰岛素抵抗,炎症和肠道微生物群.
主要成果:
- 较高的MIND饮食得分与减少的肝硬化和纤维化相关.
- 观察到胰岛素敏感性改善 (较低的HOMA-IR) 和炎症标志物 (CRP,LPS) 的降低.
- 增加肠道微生物多样性 (辛普森指数) 和较低的Firmicutes/Bacteroidetes比率与更强的MIND饮食坚持有关.
结论:
- 更多地坚持MIND饮食与MASLD患者肝脏健康指标的改善有关.
- MIND饮食对全身炎症和代谢健康有积极的影响.
- 肠道微生物多样性可能在MIND饮食对肝脏健康的有益影响中发挥部分调解作用.
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