身体圆度指数与慢性阻塞性肺病之间的相关性:一个横截面分析
Longqian Li1, Mingzhi Lin1, ZhuoLin Qin1
1The Second Clinical Medical College, Lanzhou University, Lanzhou, China.
身体圆度指数 (BRI) 与慢性阻塞性肺病 (COPD) 风险增加有关. 较高的BRI值表明风险更大,观察到值效应,表明BRI是COPD的更好的预测指标.
科学领域:
- 医学科学 医学科学 医学科学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个主要的全球健康问题.
- 腹部肥胖,特别是内脏脂肪,与COPD的发展和进展密切相关.
- 现有的措施,如脂质积累产品 (LAP),可能无法完全捕获内脏脂肪,需要探索更好的指标,如BRI.
研究的目的:
- 研究身体圆度指数 (BRI) 与慢性阻塞性肺病 (COPD) 风险之间的关联.
- 为了比较BRI与脂质积累产品 (LAP) 对COPD风险的预测性表现.
- 为了确定BRI和COPD之间的潜在值效应和剂量反应关系.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (1999-2018) 中对40岁以上的24,873名参与者的横截面分析.
- 使用多变量逻辑回归模型来评估BRI和COPD之间的关系.
- 为了验证发现,进行了灵敏度,子组,受限立方线 (RCS) 和值效应分析.
主要成果:
- 一个单位的BRI增加与5.1%的COPD风险增加有关 (95%CI:1.022-1.080,p<0.001).
- 与LAP相比,BRI显示了对COPD的优越预测能力 (AUC_BRI:0.78745与AUC_LAP:0.78675).
- RCS分析显示了BRI和COPD之间的"U形"关系,在BRI = 3.6583.3时确定了一个关键值.
结论:
- 身体圆度指数 (BRI) 是COPD风险的重要独立预测指标.
- 存在值效应,BRI值高于3.6583,表明COPD风险大幅增加.
- 与LAP相比,BRI在COPD风险评估和早期干预策略中更有效地衡量腹部脂肪分布.
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