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Updated: Jan 18, 2026

Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects
13:57

Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects

Published on: February 18, 2014

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静电相互作用会影响对抗OXA-48类β-乳酸酶的diazabicyclooctane抑制剂的功效

Joseph F Hoff1, Kirsty E Goudar1, Karina Calvopiña2

  • 1School of Cellular and Molecular Medicine, University of Bristol Bristol BS8 1TD UK Jim.Spencer@bristol.ac.uk.

RSC medicinal chemistry
|September 10, 2025
PubMed
概括

新的二甲基环氧 (DBO) 抑制剂,阿维巴克坦和纳库巴克坦,对与OXA-48类似的卡巴酶具有不同的效力. 在OXA-48中的Arg214影响了纳库巴克坦的结合,影响了耐药细菌感染的治疗策略.

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