长期COVID风险因素和结局在固体器官移植接受者中:一个回顾性队列研究
Micaela N Sandoval1, Linda W Moore2, Howard J Huang3
1Department of Epidemiology, The University of Texas Health Science Center School of Public Health, Houston, TX, United States.
Frontiers in surgery
|September 10, 2025
概括
在这项研究中,长期COVID的固体器官移植接受者与死亡或移植失败没有显著的关联. 需要进一步的研究,以了解这些脆弱患者的长期结果.
科学领域:
- 移植免疫学 移植免疫学
- 传染病流行病学 传染病流行病学
- 后病毒综合征 后病毒综合征
背景情况:
- 固体器官移植 (SOT) 接受者面临COVID-19严重疾病和死亡的风险增加.
- 这些患者也可能因后急性COVID-19综合征而遭受长期健康问题,通常称为长COVID.
研究的目的:
- 调查长期COVID对SOT接受者的移植失败和死亡率的影响.
- 基于长期COVID状态相对于移植时间来分析患者队列.
主要方法:
- 在一个主要的城市移植中心,以注册表为基础的回顾性图表审查.
- 对被诊断患有COVID-19的SOT接受者的分析,对长期COVID状态进行单独的队列.
- 评估移植失败和死亡率作为主要结局.
主要成果:
- 长期COVID被诊断在5%的SOT接受者身上 (146/3,202).
- 患有长期COVID的患者年龄较大,患有更多的并发病,更有可能成为肺,心或心肺接受者.
- 长期COVID在整体研究组中与死亡或移植失败没有显著联系,尽管在子组中观察到差异.
结论:
- 长期COVID患者和没有长期COVID患者的结果差异需要进一步调查,特别是考虑到SARS-CoV-2感染的高患病率.
- 在移植前后跟踪长期COVID患者的长度研究对于确定长期发病率和死亡率的原因至关重要.
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