营养状况,免疫营养和肠道微生物组:免疫治疗的成年期?
Elisa Mattavelli1, Francesco Agustoni2,3, Alice Tartara1
1Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Frontiers in immunology
|September 10, 2025
概括
营养状况和身体成分会影响癌症免疫治疗的有效性. 通过营养支持优化这些因素可能会改善患者的结果,尽管需要更多的研究.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 免疫疗法已经改变了癌症治疗,但在许多患者中有效性有限.
- 了解影响免疫疗法反应的因素对于改善患者存活率至关重要.
- 营养状况和身体成分越来越被认为是治疗结果的关键预测因素.
研究的目的:
- 探索营养状况和身体成分在预测癌症免疫治疗反应中的作用.
- 研究营养干预措施的潜力,以提高免疫治疗的有效性.
- 突出需要进一步研究优化免疫疗法通过营养策略.
主要方法:
- 关于免疫疗法,营养状况和癌症中的身体组成的当前文献的综述.
- 分析营养参数 (例如,,肥胖) 与免疫治疗结果之间的关联.
- 探索潜在的机制,包括肠道微生物群的调节.
主要成果:
- 营养状况不佳,肉症和低骨肌肉质量与更差的存活率和对免疫治疗的反应相关.
- 某些身体组成参数,如脂肪,可能会提高免疫治疗的疗效.
- 营养支持和特定营养素显示出改善免疫功能和治疗结果的潜力.
结论:
- 营养状况和身体成分是可修改的因素,可以显著影响癌症免疫治疗的有效性.
- 量身定制的营养支持是改善免疫治疗患者反应和生存的有希望的策略.
- 进一步的临床研究至关重要,以建立最佳的营养干预措施,以最大限度地提高免疫治疗的益处.
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