相关实验视频

Updated: May 5, 2026

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum

Published on: November 23, 2013

病例报告:急性多态精神病和血清中的NMDA-R IgG抗体:一个后续病例研究

Katharina von Zedtwitz¹, Judith Weiser¹, Raphael J Dressle¹

¹Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Frontiers in immunology

|September 10, 2025

概括

本案例研究跟踪了一名患有复发性精神病的患者,可能与抗N-甲基-D-酸盐受体 (NMDA-R) 抗体有关. 尽管最初的测试正常,但先进的成像和代谢分析表明自身免疫过程,突出显示在类似情况下需要多式诊断.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

抗N-甲基-D-酸盐受体 (NMDA-R) 脑炎是一种神经精神疾病.
精神病特征通常是由脑脊液 (CSF) 中的NMDA-R免疫球蛋白G (IgG) 抗体引起的.
这份报告详细介绍了一名疑似轻度NMDA-R脑炎患者在第一个精神病发作期间的随访情况.

研究的目的:

介绍一个患有复发性精神病的患者的随访情况.
为了研究NMDA-R抗体在患有精神病发作史的患者中的潜在作用.
探索先进诊断技术在不符合NMDA-R脑炎完全诊断标准的情况下的实用性.

主要方法:

血清NMDA-R抗体测试 (基于固定细胞的测试).
传统的MRI,EEG和CSF分析.
[18F]氧葡萄糖正子发射断层扫描 (FDG-PET) 和扩散微结构成像 (DMI).
先进的CSF抗体测试 (基于活细胞和基于组织的测试) 和质谱.
类固醇免疫疗法.

主要成果:

在复发期间检测到血清NMDA-R抗体,在没有免疫治疗的情况下随着时间的推移而减少.
传统的MRI,EEG和CSF发现在复发期间基本上是正常的.
FDG-PET和DMI显示了持续的,虽然减少了,代谢和微观结构的改变.
先进的CSF测试对NMDA-R IgG抗体呈阴性;质谱学表明神经递质前体缺乏.
类固醇免疫疗法导致残留症状的临床改善.

结论:

该患者没有满足NMDA-R脑炎的国际共识标准,原因是CSF抗体结果呈阴性,常规发现不显眼.
尽管CSF的发现是负面的,但存在自身免疫过程的迹象.
多模式诊断方法,包括补充抗体测试,可能有助于理解类似的复杂病例.

关键词:

这是一种自身免疫性疾病.自身免疫性脑炎的发生.大脑大脑大脑的大脑大脑免疫疗法免疫疗法这是一种炎症炎症炎症炎症.

更多相关视频

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood

Published on: January 9, 2018

Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis

Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis

Published on: June 2, 2022

相关概念视频

Encephalitis l: Introduction

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...