反复性周周小神经综合征对高剂量阿弗利塞普特治疗有反应
Alessandro Feo1,2, Neda Abraham1, Mostafa Mafi1
1Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California of Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Retinal cases & brief reports
|September 10, 2025
概括
高剂量静脉注射aflibercept注射有效地治疗了反抗性的双边周周皮囊性帕奇科罗伊德综合征 (PPS). 这种疗法导致显著的液体分离,减少胸膜厚度,并在患有持续性黄斑的患者中改善视力.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 血管生物学 血管生物学
背景情况:
- 周 papillary 帕奇科罗伊德综合征 (PPS) 是一种状况,其特征是液体积累和胆管的加厚.
- 复发性PPS病例往往对标准治疗反应有限,这构成了临床挑战.
研究的目的:
- 报告一种对常规疗法有抗性的双边周周毛囊性松症候群 (PPS) 的病例.
- 评估高剂量 (HD) 静脉注射aflibercept注射在治疗反抗性PPS时的疗效.
主要方法:
- 对单个双边PPS患者的医学和成像数据的回顾性分析.
- 利用多式成像技术,包括超广场绿色和光素血管学, fundus自光学和OCT血管学.
- 通过OCT B扫描评估了内液 (IRF),下液 (SRF) 和胆道厚度 (CT).
主要成果:
- 一名75岁的男性患有严重的双边PPS和,经过先前的治疗 (光动力学疗法,标准aflibercept,皮质类固醇) 显示出最小的改善.
- 在每月两次静脉内 HD aflibercept 注射后,观察到周围毛囊和黄斑液几乎完全消失.
- 在两只眼睛中都注意到显著的视力敏度增长和胸膜厚度的减少.
结论:
- 高剂量静脉内服阿弗利塞普特显示出作为对固的周周巴皮拉性帕奇科罗伊德综合征 (PPS) 的有效治疗潜力.
- 这种治疗方法可以在具有挑战性的PPS病例中提供实质性的解剖和功能恢复.
相关概念视频
01:27Open Angle Glaucoma: Treatment
963
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
963
01:28Angle Closure Glaucoma: Treatment
1.2K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.2K