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在单胆双胞胎中产周围动脉缺血性中风:回顾性观察单中心队列研究

Bregje O van Oldenmark¹, Mathies Rondagh¹, Phebe Adama van Scheltema²

¹Division of Neonatology, Department of Pediatrics, Willem-Alexander Children's Hospital (B.O.v.O., M.R., M.S.S., E.L., L.S.d.V., S.J.S.), Leiden University Medical Center, the Netherlands.

|September 10, 2025

概括

围产期动脉缺血性中风 (PAIS) 影响受体单双胞胎,通常是由于怀孕并发症. 早期的神经成像对于及时干预和康复至关重要.

科学领域:

新生儿神经学新生儿神经学
产周医学产周医学
儿科神经学儿科神经学

背景情况:

双胞胎共用一个胎盘,增加脑损伤的风险,如围产期动脉缺血性中风 (PAIS).
在这些双胞胎中,PAIS的确切原因和时间尚未完全理解.

研究的目的:

为了调查PAIS的发病率,时间,风险因素和结果在单双胞胎中.
识别特定的中风模式和相关的神经发育障碍.

主要方法:

在荷兰推中心对2005-2024年期间确诊PAIS的单胆双胞胎进行了回顾性队列研究.
PAIS发病的分类 (产前,产周,产后) 和风险因素和神经发育结果的评估.

主要成果:

在1183对双胞胎中,1.5%患有PAIS,在双胞胎对双胞胎输血综合征的情况下,主要影响接受双胞胎 (86%).
PAIS发生在产前 (6),产周 (7),产后 (5),中脑动脉参与的56%.
结果包括脑和半,主要分支中脑动脉中风的死亡率更高.

结论:

一子双胞胎的PAIS与妊娠并发症有关,并且最常影响受孕双胞胎.
脑卒中可以发生在产前,产周或产后,具有不同的模式和显著的神经发育后果.
建议对复杂的单胆双胞胎进行胎儿和产后神经成像,以实现PAIS的早期检测和康复.

关键词:

缺血性中风中风磁共振成像技术的使用胎盘胎盘胎盘胎盘怀孕怀孕怀孕怀孕怀孕他们是双胞胎,双胞胎.

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