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-PET转换中的等离子体生物标记物的预测价值
Jonathan Graff-Radford1, Jeremy A Syrjanen2, Prashanthi Vemuri3
1Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Annals of neurology
|September 10, 2025
概括
化的 (%p-tau217) 和粉胺-PET成像在阿尔茨海默病研究中有效预测-PET转化. 这些生物标志物对疾病进展具有可比的预测价值.
科学领域:
- 神经学 神经学
- 生物标志物研究 生物标志物研究
- 阿尔茨海默氏症疾病的诊断方法
背景情况:
- 阿尔茨海默病 (AD) 诊断依赖于识别核心神经病理变化,包括粉样质斑块和团.
- 准确预测神经退行性进展对于临床试验招生和治疗开发至关重要.
研究的目的:
- 评估化陶 (%p-tau217) 和粉胺-PET对未来陶-PET阳性的预测能力.
- 评估将血生物标记物 (粉样蛋白-β 42/40和%p-tau217) 结合成粉样蛋白概率评分 (APS2) 的附加值.
主要方法:
- 利用了梅奥诊所衰老研究 (MCSA) 和BioFINDER-2队列的数据.
- 采用Cox的比例危险模型来分析血%p-tau217,粉样蛋白-PET百叶状物和血Aβ42/40比率作为tau-PET转换的预测因素.
- 根据年龄,性别和阿波利波蛋白E ε4 (APOE ε4) 状态进行调整的模型.
主要成果:
- 较高的血%p-tau217和粉样蛋白-PET百分位蛋白值显著预测了在两个队列中转化为tau-PET阳性状态.
- 粉样蛋白概率得分 (APS2) 预测了MCSA队列中的转化.
- 血Aβ42/40比率预测了BioFINDER-2队列中的转化,其中包括更多的认知障碍患者.
结论:
- 血%p-tau217作为一个有价值的生物标志物用于预测tau-PET转化,表现出与粉样PET相比的性能.
- 结合的血生物标志物 (APS2) 和特定的血Aβ比率为AD研究中tau-PET过渡提供了补充的预测信息.
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