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APD6:抗微生物数据库扩展,通过部署前所未有的信息管道来促进研究和开发

Guangshun Wang¹, Cindy Schmidt¹, Xia Li¹

¹Department of Pathology, Microbiology and Immunology, College of Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE 68198-5900, United States.

Nucleic acids research

|September 10, 2025

概括

抗微生物数据库版本6 (APD6) 通过提供具有广泛数据的全面平台来增强抗微生物 (AMP) 研究. 这种资源有助于开发新的基于的抗生素和治疗药物.

科学领域:

生物化学生物化学
药理学药理学是指药理学的学科.
生物信息学是一种生物信息学.

背景情况:

抗生素耐药性的增加需要新的治疗策略.
主体防御抗微生物 (AMP) 是下一代抗生素的有希望的候选者.
现有的数据库和用于AMP的预测工具在范围和预测能力方面存在局限性.

研究的目的:

引入抗微生物数据库版本6 (APD6),这是一个针对AMP信息的综合平台.
促进AMP作为新型抗生素和治疗药物的发展.
为AMP提供全面的数据集,以推进人工智能 (AI) 预测模型的发展.

主要方法:

将AMP数据整合到一个统一的数据库平台 (APD6).
开发抗微生物信息管道 (AMPIP) 以提供全面的数据覆盖.
扩大的功能分类,包括除了抗生素之外的治疗应用.

主要成果:

截至2025年3月18日,APD6拥有5188个记录 (3306个天然,1380个合成,239个预测).
该数据库提供了自然AMP的精细数据集,这对于的设计和预测至关重要.
APD6提供了新的正和负数据集 (例如,pH,盐,血清效应,耐药性),以改善AI驱动的抗生素发现.

结论:

APD6是推动AMP研发的重要资源.
该数据库有助于创建更强大的AI模型,用于识别新型抗生素.
APD6支持探索AMP用于超越其抗菌性能的治疗应用,例如抗癌和抗糖尿病药物.

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