关于SARS-CoV-2传播的共享房间通风和过的风险降低:一个多中心测试负的多中心研究
Victoria Williams1, Kevin L Schwartz2,3,4, Kevin Brown3,4
1Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Infection control and hospital epidemiology
|September 10, 2025
概括
医院房间通风的改善,包括每小时的空气变化 (ACH) 和机械通风 (RMV),显著降低了暴露患者中与医疗保健相关的SARS-CoV-2感染的几率. 便携式HEPA过器没有显著影响.
科学领域:
- 传染性疾病 传染性疾病
- 环境健康 环境健康
- 医院流行病学 医院流行病学
背景情况:
- 共享医院房间是与医疗保健相关的SARS-CoV-2传播的重要风险因素.
- 对通风和过等工程控制的影响量化对于感染预防策略至关重要.
研究的目的:
- 评估工程控制对共享医院病房中SARS-CoV-2传播的影响.
- 为了评估每小时空气更换 (ACH),房间机械通风 (RMV) 和便携式高效颗粒空气 (HEPA) 过器的有效性.
主要方法:
- 一项多中心检测负的研究,涉及468名在共享房间中暴露于SARS-CoV-2的患者.
- 利用多层次的物流混合模型来分析工程控制和感染传播之间的关联.
- 独立变量包括ACH,RMV和HEPA过器的存在;共变量包括患者和设施因素.
主要成果:
- 暴露患者中的二次攻击率为26.3%.
- 增加的ACH (aOR 0.88) 和RMV的存在 (aOR 0.51) 独立地与SARS-CoV-2感染的几率降低有关.
- 便携式HEPA过器的使用没有统计学意义 (aOR 0.58).
结论:
- 增强通风,特别是优化 ACH 和 RMV,可以显著降低在共享医院病房中传播 HA-SARS-CoV-2 的风险.
- 需要进一步的研究来确定最佳的ACH值和HEPA过器的作用.
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