系统性硬化和与系统性硬化相关的间歇性肺病的现实世界治疗:来自日本医院索赔数据库的信息
Takashi Funatogawa1, Kazuma Mii1, Kazuki Kojima1
1Oncology Clinical Development Department, Chugai Pharmaceutical Co., Ltd, 1-1 Nihonbashi-Muromachi 2-Chome, Chuo-ku, Tokyo 103-8324, Japan.
Modern rheumatology
|September 10, 2025
概括
最近在日本用于系统性硬化症 (SSc) 和间歇性肺病 (ILD) 的SSc的药物使用越来越符合EULAR指南. 利图西马布的使用显著增加,在随后的治疗中常见的是宁泰达尼布和mycophenolate mofetil.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 系统性硬化症 (SSc) 是一种慢性自身免疫性疾病.
- 间歇性肺病 (ILD) 是SSc的一个主要并发症.
- 2023年EULAR指南建议针对SSc-ILD进行特定的治疗.
研究的目的:
- 调查日本最近对SSc和SSc-ILD推药物的实际使用情况.
- 将目前的药物使用情况与2023年EULAR建议进行比较.
主要方法:
- 对2020-2023年日本医院索赔数据库的分析.
- 包括SSc (ICD-10 M34.x) 和/或ILD代码的患者.
- 包括具有共存自身免疫性疾病代码的患者.
主要成果:
- 14,522名SSc患者:14.3%接受小分子药物,4.3%接受生物药物.
- 常见的第一线SSc治疗方法:美托特雷克萨特,宁特丹尼布,塔克罗利斯,甲酸莫菲蒂尔 (MMF),利图西马布,托西利祖马布.
- 4,890名SSc-ILD患者:22.1%接受小分子药物,5.8%接受生物药物.
- 常见的第一线SSc-ILD治疗方法:宁泰达尼布,塔克罗利斯,MMF,修复药,托西利祖马布.
- 利图西马布在SSc和SSc-ILD (2020-2023) 中使用率增长最快.
- 在Rituximab或Cyclophosphamide之后的后续治疗包括Nintedanib,MMF和Rituximab.
结论:
- 日本实际使用毒品的情况越来越符合EULAR对SSc和SSc-ILD的建议.
- 这项研究强调了越来越多的人采用推疗法,特别是像Rituximab这样的生物药物.
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