抑制性神经元变异性在合网络之间调节相位多样性的作用
Katiele V P Brito1,2, Joana M G L Silva1, Claudio R Mirasso2
1Instituto de Física, Universidade Federal de Alagoas, Maceió, Alagoas 57072-970, Brazil.
Chaos (Woodbury, N.Y.)
|September 10, 2025
概括
抑制网络中的神经元异质性会影响大脑区域的通信. 这项研究揭示了多种抑制性神经元类型如何驱动相位多样性和同步模式,影响认知功能.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 神经元异质性,特别是在抑制性神经元中,在大脑中很普遍.
- 尽管异质性可能会减少同步,但在认知任务期间,皮质区域表现出连贯的振荡.
- 神经元异质性的功能作用,特别是在区域间的通信中,正在研究中.
研究的目的:
- 探索多种抑制性神经元类型如何促进两个皮层区域之间的不同相位关系.
- 研究局部神经元特性的影响,如异质性,在遥远的大脑区域之间的通信.
- 阐明同步转换背后的机制及其与认知现象的关系.
主要方法:
- 同质和异质抑制神经网络的建模.
- 分析相位关系,同步模式 (延迟同步和预期同步) 和相位稳定性.
- 研究抑制异质性参数对网络动态的影响.
主要成果:
- 均质和异质网络都显示相位多样性,预期同步 (AS) 和相位稳定性.
- 神经元异质性扩大了零滞时同步和双稳定的参数空间.
- 抑制性的异质性调节了从延迟同步 (DS) 到AS的过渡,可能是通过零延迟同步或双稳定性.
- 异质性影响自由运行的神经元群体的内部动态.
结论:
- 抑制性神经元异质性在塑造区域间通信动态方面发挥着至关重要的作用.
- 该研究提出了一个DS-AS过渡的机制,涉及零延迟同步和相位稳定,与认知过程相关.
- 神经元异质性可以导致复杂的同步模式,在认知任务中提供对大脑功能的洞察.
相关概念视频
01:29Excitatory and Inhibitory Effects of Neurotransmitters
12.7K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
12.7K
01:25Neural Circuits
2.7K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
2.7K
01:19The Role of Ion Channels in Neuronal Computation
3.7K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.7K
01:25Network Function of a Circuit
653
Frequency response analysis in electrical circuits provides vital insights into a circuit's behavior as the frequency of the input signal changes. The transfer function, a mathematical tool, is instrumental in understanding this behavior. It defines the relationship between phasor output and input and comes in four types: voltage gain, current gain, transfer impedance, and transfer admittance. The critical components of the transfer function are the poles and zeros.
653
01:28Neuronal Communication
3.1K
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
3.1K
01:23Propagation of Action Potentials
9.0K
The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
9.0K