结直肠癌的下一代纳米载体:用于精密治疗的被动,主动和刺激响应策略
Rehab Galal Abbas Mohamed1, Salma Mohamed Ali1, Iman Saad Ahmed1,2
1Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates. zahidh85@yahoo.com.
Biomaterials science
|September 10, 2025
概括
纳米载体通过向瘤和降低毒性,提供先进结直肠癌 (CRC) 治疗. 未来的CRC纳米医学需要智能,模块化设计和个性化的方法,以获得更好的患者结果.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 结肠直肠癌 (CRC) 构成了重大的全球健康挑战,推动了改善治疗策略的需求.
- 基于纳米载体的药物输送系统显示出提高CRC治疗效率和安全性的前景.
研究的目的:
- 审查最近纳米载体用于结肠直肠癌 (CRC) 治疗的进展.
- 要突出新兴的趋势,挑战和未来的方向在CRC纳米医学.
主要方法:
- 关于被动准 (EPR效应) 和主动准 (连带) 策略的概述.
- 探索对刺激反应的纳米载体系统 (pH,氧化还原,酶,光,热,磁场).
- 讨论用于theranostics和个性化医学的多功能和混合纳米平台.
主要成果:
- 纳米载体增强瘤药物积累,减少目标外毒性.
- 体工程纳米系统和多刺激响应设计代表了新兴的前沿.
- 临床前研究显示有希望,但临床翻译面临着可扩展性和瘤异质性等障碍.
结论:
- 纳米技术为改善CRC治疗和患者预后提供了有前途的途径.
- 未来的研究应该集中在理性设计,机器学习集成和CRC的个性化纳米医学上.
- 解决翻译挑战对于实现纳米载体在CRC治疗中的全部潜力至关重要.
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