贝塔宁和黄素以以基体为基础的输送,以提高抗炎功效
Sangameshwar B Kanthale1, Vaibhav Bharad1, Prakash Kendre1
1Department of Pharmaceutics, Rajarshi Shahu College of Pharmacy, Buldana, Maharashtra, India.
Journal of drug targeting
|September 10, 2025
概括
这项研究创建了一种以索姆凝,以改善贝塔宁和黄素的输送,以增强抗炎作用. 这种新型配方显示改善了皮肤透和持续的治疗作用.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 在治疗中纳米技术.
- 自然产品化学 自然产品化学
背景情况:
- 贝塔宁和黄素具有抗氧化和抗炎性质,但其生物利用性较差,并无法透到皮肤中.
- 开发有效的局部输送系统对于利用这些植物成分的治疗潜力至关重要.
研究的目的:
- 开发和表征一种以基基凝,用于增强贝宁和黄素的通过皮肤传递.
- 为了评估开发的生体凝的持续抗炎作用和皮肤兼容性.
主要方法:
- 含有贝塔宁和库尔库明的以太体用冷方法制成,并针对粒子大小,泽塔潜力和捕获效率进行了优化.
- 物理化学表征包括SEM,FT-IR,pH,粘度和扩散性评估.
- 在实验室扩散,皮肤刺激测试和体内抗炎研究使用卡拉基安诱导的老鼠模型进行.
主要成果:
- 优化的乙体具有202.8纳米的粒子大小,-56.4mV的泽塔潜力,以及高的捕获效率 (80%的贝塔宁,85%的黄素).
- 乙体凝表现出适合局部应用的特性 (pH6.5,伪塑性粘度,良好的扩散性),并显示持续释放8小时.
- 在体内研究证实了炎症的显著减弱,皮肤刺激测试表明良好的生物相容性.
结论:
- 基于乙体的凝配方有效地增强了贝塔宁和黄素的通过皮肤传递和抗炎疗效.
- 这种方法为开发利用天然抗炎剂的先进局部治疗提供了一个有希望的策略.
相关概念视频
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
200
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
200
Bioavailability Enhancement: Drug Permeability Enhancement
191
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
191
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
506
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
506
Drug Delivery: Miscellaneous Routes
716
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
716


