相关实验视频
Updated: Jan 18, 2026

09:38
Direct Reprogramming of Mouse Fibroblasts into Melanocytes
Published on: August 27, 2021
2.5K
[维地利戈] 维地利戈是什么意思
Sanne E Uitentuis1,2, Marcel W Bekkenk1, Patrick M J H Kemperman1
1Amsterdam UMC, Nederlands Instituut voor Pigmentstoornissen (SNIP), Amsterdam.
Nederlands tijdschrift voor geneeskunde
|September 10, 2025
概括
Vitiligo 是一种自身免疫性皮肤疾病,通过破坏黑色素细胞引起白斑. 像JAK抑制剂这样的新疗法在阻止进展和重新颜色化方面表现有前途.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 自免疫性疾病 自免疫性疾病
背景情况:
- Vitiligo 是一种慢性皮肤疾病,由于黑色素细胞的破坏导致皮肤色素丧失.
- 非细分性白风呈现出对称的斑块和可变的进展.
- 这种情况涉及到一种通过细胞毒性T细胞向黑色素细胞的自身免疫反应.
研究的目的:
- 总结目前对白风的理解和治疗.
- 为了突出白风治疗的最新进展.
主要方法:
- 审查关于白风病原和治疗的现有文献.
- 对新出现的治疗选择进行分析.
主要成果:
- 目前的治疗方法包括局部/光疗,皮质类固醇或手术.
- 简氏激酶 (JAK) 抑制剂代表了一种新的治疗方法.
结论:
- Vitiligo 治疗的重点是阻止疾病的进展,并实现再发色.
- 雅克抑制剂为白风治疗提供了有前途的新途径.
相关概念视频
Skin Diseases and Disorders
5.2K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.2K
Changes in Skin Color: Clinical Perspectives
3.3K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.3K
Pigmentation
4.1K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.1K
Skin Cancer
5.7K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.7K
Papillary Dermis
5.5K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.5K
Accessory Structures of the Skin: Hair Growth and Types
2.3K
Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
2.3K

