噪音引起听力损失患者皮质结构异常:基于表面的形态学研究
Yunxin Li1, Ranran Huang1, Aijie Wang1
1Radiology Department, Yantaishan Hospital, Yantai, Shandong, China.
Brain and behavior
|September 10, 2025
概括
噪音引起的听力损失 (NIHL) 改变了大脑结构,特别是在听觉视觉网络区域,如叶和叶. 这些变化与听力障碍和焦虑相关,为NIHL神经生物学提供了新的见解.
科学领域:
- 神经成像是一种神经成像.
- 听觉神经科学 听觉神经科学
- 神经可塑性 神经可塑性
背景情况:
- 噪音引起的听力损失 (NIHL) 是一个日益严重的公共卫生问题.
- NIHL对大脑结构和功能的影响尚未完全理解.
- 基于源的形态测量 (SBM) 提供了一种新的方法来研究NIHL中的大脑变化.
研究的目的:
- 用SBM来描述NIHL患者的大脑结构的变化.
- 探索改变的大脑区域和NIHL的临床数据之间的相关性.
- 阐明NIHL背后的神经生物学机制.
主要方法:
- 从81名NIHL患者和74名健康对照 (HC) 获得了高分辨率的3D T1结构性MRI扫描.
- 收集的临床数据包括噪音暴露,听力值 (MTWV),MMSE和HAMA分数.
- 使用FreeSurfer进行全脑SBM分析,以评估皮质厚度,表面积和体积.
主要成果:
- 在NIHL患者中,左下垂体环 (IPG) 和右上垂体环 (SPG) 的皮层厚度增加.
- 在NIHL患者的左侧尾环 (LOG) 中观察到表面积和体积的增加.
- 皮层变化与单声听力值加权值 (MTWV) 和汉密尔顿焦虑量表 (HAMA) 分数相关.
结论:
- 在听觉视觉网络区域内,NIHL与皮质形态的显著变化有关.
- 这些结构变化表明听觉剥夺可以诱导皮质结构重组.
- 这些发现为NIHL中神经生物学和大脑活动异常提供了新的见解.
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