主体病原体共同进化的结果对宏观流行病的影响,基于联合主体战略
Qiutong Liu1, Yanni Xiao2, Stacey R Smith3
1School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an, 710049, PR China.
Bulletin of mathematical biology
|September 10, 2025
概括
宿主-病原体共同进化可以改变疾病动态,潜在地减少了只存在病原体进化的"水效应". 这项研究探讨了这些相互作用如何影响感染模式和患病率.
科学领域:
- 进化生物学是进化的生物学.
- 流行病学 流行病学
- 数学建模的数学建模
背景情况:
- 宿主防御和病原体毒性是共同进化的特征.
- 同进化结果显著影响人口动态和疾病传播.
- 了解微观层面的共同进化对于宏观层面的流行病预测至关重要.
研究的目的:
- 通过共同进化模型研究宿主-病原体相互作用.
- 探索宿主-病原体共同进化对流行病动态的影响.
- 分析联合宿主防御策略对疾病传播的影响.
主要方法:
- 开发一种结合宿主防御和病原体毒性的共同进化模型.
- 在不同的进化场景下模拟宿主-病原体相互作用.
- 分析感染循环,疾病流行率和致死率.
主要成果:
- 主体-病原体的共同进化可以诱导感染循环,并减少疾病诱导的水效应.
- 病原体单进化在范围和强度上都放大了水效应.
- 在共同进化下增加的康复率可以矛盾地增加疾病患病率,从高致死率转变为低致死率.
结论:
- 联合的共同进化和流行病学框架为复杂的感染动态提供了洞察力.
- 宿主-病原体共同进化在塑造流行病模式方面发挥着至关重要的作用.
- 了解这些相互作用对于预测和管理传染病至关重要.
更多相关视频
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
3.1K
13:56A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
Published on: July 18, 2013
11.6K
相关概念视频
Gene Flow
37.5K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
37.5K
Infection
11.9K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.9K
Causality in Epidemiology
1.5K
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.5K
Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
Stages of Infection
65.0K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
65.0K
