辐射诱导的延迟发作的微观结构灰质变化的MRI评估 鼻癌患者的鼻癌患者
Ziru Qiu1, Gui Fu2, Yuhao Lin3
1School of Biomedical Engineering, Guangdong Provincial Key Laboratory of Medical Image Processing and Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China.
Journal of magnetic resonance imaging : JMRI
|September 10, 2025
概括
鼻癌的放射治疗导致叶灰质物质的延迟变化,影响大脑结构. 脑内皮层和极中的这些微观结构变化有助于叶缩.
科学领域:
- 神经成像是一种神经成像.
- 放射治疗研究 放射治疗研究
- 在瘤学瘤学.
背景情况:
- 放射治疗 (RT) 后灰质 (GM) 微观结构变化的进展及其与患者皮质形态变化的联系尚不清楚.
- 了解这些变化对于管理癌症治疗潜在的长期神经系统副作用至关重要.
研究的目的:
- 在鼻癌 (NPC) 患者中纵向研究RT诱导的GM微观结构变化.
- 确定这些微观结构变化和叶 (TL) 的形态变化之间的关系.
主要方法:
- 一项前性的纵向研究,涉及40名NPC患者和20名健康对照.
- 3T MRI (3D T1加权和多扩散加权成像) 用于在RT后的多个时间点获取数据.
- 基于灰质的空间统计和基于表面的形态测量被用于分别分析微观结构和宏观结构的变化.
主要成果:
- 延迟发生的转基因微观结构变化在TL地区出现于RT后6-12个月.
- 在内皮层 (EC) 和极 (TP) 中观察到剂量依赖的扩散指标变化.
- 调解分析显示,延迟EC和TP变化导致了广泛的TL缩.
结论:
- 对NPC的放射治疗诱导了EC和TP的延迟发病,剂量敏感的微观结构变化.
- 这些微观结构变化在更广泛的TL缩的发展中起着因果作用.
- 这些发现强调了在NPC患者的RT后监测叶完整性的重要性.
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