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Updated: Jan 6, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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在肝细胞癌中对CDK20抑制剂进行量子化学优化和残留特异性稳定

Ahmed I Foudah1, Mohammed H Alqarni1, Tariq M Aljarba1

  • 1Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al Kharj, Saudi Arabia.

Molecular diversity
|September 10, 2025
PubMed
概括

研究人员确定了一种新型化合物153295720,作为循环素依赖激酶20 (CDK20) 的强有力的抑制剂. 这一发现提供了一个有希望的策略,通过稳定关键的CDK20残留物来准肝细胞癌 (HCC).

关键词:
在CDK20中使用CDK20癌症 癌症 癌症 癌症在 DFT 方面,它是最重要的.肝细胞癌是肝细胞癌.分子动力学分子动力学

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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma12:24

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