在老年黑人和西班牙裔患有心力衰竭的个体中发生过静素心脏粉症
Frederick L Ruberg1,2, Sergio Teruya3, Stephen Helmke3
1Section of Cardiovascular Medicine, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts.
JAMA cardiology
|September 10, 2025
概括
黑人心脏粉症 (ATTR-CA) 是老年黑人心脏衰竭的重要原因,尤其是75岁以上的男性. 这项研究发现,黑人参与者的ATTR-CA患病率为7.82%,突出显示其诊断不足.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 晶氨酸心肌粉症 (ATTR-CA) 是老年人心力衰竭 (HF) 的未被确诊的原因.
- 它可以是野生型 (ATTRwt-CA) 或由于TTR基因变异而遗传 (ATTRv-CA).
- V142I变种在黑人美国人中很常见,但在这个人群中ATTR-CA的流行率是未知的.
研究的目的:
- 为了确定ATTR-CA在老年黑人和加勒比海西班牙裔HF个体中的患病率.
- 为了确定由于野生型 (ATTRwt-CA) 或变异型 (ATTRv-CA) TTR基因导致的ATTR-CA病例的比例.
主要方法:
- 对60岁以上患有HF的个体进行前性,多中心,横截面研究.
- 通过放射性核酸成像进行ATTR-CA诊断,不包括血液测试的轻链氨基粉症.
- 基因定型用于识别TTR基因变异;收集心声学,生化和生活质量数据.
主要成果:
- 在646名参与者中,ATTR-CA的总体患病率为6.66%.
- 在黑人 (7.82%) 和西班牙裔 (2.15%) 个体中,患病率更高 (P=.004).
- 在黑人参与者中,ATTR-CA在男性 (8.15%) 和75岁以上 (14.04%) 的人群中更常见.
结论:
- 在年长的黑人中,ATTR-CA是导致HF的重要原因,特别是75岁以上的男性.
- 大约一半的V142I携带HF的携带者有ATTR-CA.
- 在这个队列中,超过一半的ATTR-CA病例具有正常的TTR基因型.
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