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酵母菌对金属的交叉耐受性的演变

Anna L Bazzicalupo^1,2, Penelope C Kahn¹, Eully Ao^1,3

¹Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Proceedings of the National Academy of Sciences of the United States of America

|September 10, 2025

概括

适应一种金属应力的生物可以对其他金属表现出不同的耐受性. 适应导致了通用主义者,而适应导致了专家,代谢基因是广泛交叉耐受性的关键.

科学领域:

环境微生物学环境微生物学
进化生物学是进化的生物学.
遗传学是一个遗传学.

背景情况:

生物经常同时遇到多个环境压力因素.
了解对不同压力因素的交叉耐受性 (或不耐受性) 对于预测进化反应至关重要.
适应单一的压力因素可能会给他人带来意想不到的交叉耐受性或不耐受性.

研究的目的:

为了研究适应单金属压力因素的*Saccharomyces cerevisiae*的交叉耐受性模式.
根据金属特性,基因重叠和环境共发生,确定交叉耐受性的预测因素.
为了揭示金属交叉耐受性的遗传基础.

主要方法:

麦片菌 (Saccharomyces cerevisiae) 适应六种不同的单金属压力.
测量对五种其他金属的交叉耐受性,用于每个调整的线.
109个金属适应系的基因组测序.
对基因突变的分析,特别是在代谢基因中.

主要成果:

适应特定的金属,而不是生理化学相似性或基因重叠,是交叉耐受性最强的预测因素.
适应的酵母表现出广泛的交叉耐受性 (通用主义者),而适应的酵母表现出专门的耐受性 (专家).
代谢基因 (*PHO84*, *SIW14*, *VTC4*) 的突变与更广泛的交叉耐受性有关.
某些金属 (,,) 影响了突变谱.

结论:

基于简单的因素来预测交叉耐受性是一个挑战.
特定的遗传途径,如代谢,可以调解对多种金属压力因素的广泛交叉耐受性.
对一个压力因素的进化适应可以导致复杂的,非直观的交叉耐受性模式.

关键词:

这种植物是Saccharomyces cerevisiae.适应适应适应适应实验进化的实验进化.类型的类型.救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援救援

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