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从敏感性到耐受性:对儿科患者树果和花生过敏的回顾性研究
Damla Baysal Bakır1, Özge Atay1, Halime Yağmur1
1Division of Pediatric Immunology and Allergy, Department of Child Health and Diseases, Dokuz Eylul University, İzmir, Turkey.
International archives of allergy and immunology
|September 10, 2025
概括
儿童树果/花生 (TN/PN) 过敏往往是严重和持久的. 诸如多种坚果过敏,花粉敏感性和较大的皮肤测试反应等关键指标预测了长期的过敏和过敏反应风险.
科学领域:
- 儿科过敏和免疫学
- 临床免疫学临床免疫学
- 食物过敏研究 食物过敏研究
背景情况:
- 树果/花生 (TN/PN) 过敏在儿童中很普遍,经常持续并带来重大风险.
- 在儿科TN/PN过敏中预测耐受性发展和过敏反应风险仍然具有挑战性.
- 了解影响TN/PN过敏结果的因素对于临床管理至关重要.
研究的目的:
- 评估与儿科TN/PN过敏中过敏风险相关的临床和实验室特征.
- 确定预测TN/PN过敏儿童耐受性发展的因素.
- 检查空气过敏原敏感化,亚托皮性疾病和皮肤测试反应性对TN/PN过敏结果的影响.
主要方法:
- 对121名被诊断为TN/PN过敏的儿童 (0-18岁) 的回顾性分析.
- 收集的数据包括反应史,并发病症,IgE水平,乙酸蛋白和刺刺 (PTP) 试验小麦大小.
- 通过口服食物挑战,再暴露和临床随访来定义的耐受性.
主要成果:
- 多种坚果过敏 (81%) 是常见的;花和 pistachio 是最常见的.
- 过敏反应发生在36%的病例中;在随访期间,25%的患者产生了耐受性.
- 空气过敏原敏感性和较大的PTP小麦大小与持续的过敏和更高的过敏反应风险有关.
结论:
- 儿科TN/PN过敏往往是严重和持久的.
- 多种坚果过敏,空气过敏原敏感性和较大的PTP小麦大小是长期过敏和过敏反应的危险因素.
- 早期识别这些标志物可以改善风险分层,并指导个性化的后续行动.
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