在炎症性肠病患者中进行皮下vedolizumab剂量强化:来自GETAID的OPTI-VEDO多中心研究
Pauline Wils1,2, Romain Altwegg3, Anthony Buisson4
1Department of Gastroenterology, Claude Huriez Hospital, University of Lille 2, Lille, France.
Journal of Crohn's & colitis
|September 10, 2025
概括
皮下vedolizumab (SC VDZ) 剂量强化在不完全反应的炎症性肠病 (IBD) 患者中显示出有效性. 这项现实研究发现,在3个月内,至少三分之一的IBD患者的临床反应没有使用类固醇.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在炎症性肠病 (IBD) 中,关于皮下vedolizumab (SC VDZ) 剂量升级的现实数据有限.
- SC VDZ是一种常见的IBD生物疗法.
- 评估SC VDZ强化策略对于优化患者治疗结果至关重要.
研究的目的:
- 评估皮下注射维多利祖马布 (SC VDZ) 剂量强化在IBD患者中的有效性和安全性.
- 为了确定 SC VDZ 加剧后无类固醇临床响应 (SFCr) 的速率.
- 在经历SC VDZ强化的IBD患者中识别与治疗反应相关的因素.
主要方法:
- 在25个中心进行了回顾性研究.
- 包括患有活性性结肠炎 (UC) 或克罗恩病 (CD) 的患者,他们对SC VDZ 108 mg每隔一周不完全反应或失去反应.
- 主要结局:3个月后无类固醇临床响应 (SFCr),定义为PRO2改善,没有治疗变化,没有手术,以及SC VDZ持久性.
主要成果:
- 包括154名患者 (66%的UC,34%的CD).
- 在3个月后,SFCr在35%的CD患者和43%的UC患者中实现.
- 与响应相关的因素包括CD中的二次响应丧失和UC中的先前抗TNF暴露. 51%的CD患者和37%的UC患者在12个月后保持了SC VDZ. 不良事件很少发生.
结论:
- 在3个月后,SC VDZ强化在至少三分之一的IBD患者中提供了临床益处.
- 这种策略在现实世界临床实践中是有效的,用于管理IBD.
- 进一步的研究可能会探索SC VDZ强化反应的最佳时间和预测因素.
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