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Updated: Jul 15, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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在分子瘤分析结果的回报方面存在挑战

Heinz-Josef Lenz1, David W Craig2, Kevin C Johnson3

  • 1USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Journal of the National Cancer Institute
|September 10, 2025
PubMed
概括

下一代测序 (NGS) 提供了重要的癌症见解,但在临床使用中面临挑战. 优化体质报告时间,标准化和患者参与度可以改善其对精确瘤学的影响.

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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...