相关实验视频
Updated: Jan 18, 2026

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A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
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在社区动脉样硬化风险研究中,嗅觉不佳和心力衰竭风险
Keran W Chamberlin1, Chenxi Li1, Anna Kucharska-Newton2
1Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, Michigan, United States.
概括
嗅觉差 (嗅觉丧失) 与老年人心力衰竭 (HF) 的风险更高有关. 这种嗅觉障碍特别与减少喷射分数 (HFrEF) 的HF有关.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 神经学 神经学
背景情况:
- 嗅觉功能障碍是心血管疾病的潜在早期指标.
- 关于老年人嗅觉不良与发生心力衰竭 (HF) 之间的关联,有有限的经验数据.
研究的目的:
- 在一大群老年人中调查嗅觉功能与发生性HF之间的关联.
- 检查嗅觉和HF亚型 (HFrEF,HFpEF) 和亚临床HF生物标志物之间的关系.
主要方法:
- 利用了来自社区动脉样硬化风险研究的5217名参与者的数据,使用Sniffin' Sticks测试来评估嗅觉.
- 将嗅觉分类为好,中等或差,并在平均8.4年内对HF住院患者进行了随访.
- 评估了与HF,HF亚型和亚临床标志物的关联,包括NT-proBNP,hs-cTnT和结构性心脏病.
主要成果:
- 糟糕的嗅觉与8年内发生HF风险的轻微增加有关 (aRR为1.24).
- 这种关联对于具有减少喷射分数 (HFrEF) 的HF比具有保存喷射分数 (HFpEF) 的HF更为明显.
- 糟糕的嗅觉与高的NT-proBNP,hs-cTnT水平相关,并增加了结构性心脏病的几率.
结论:
- 通过嗅觉测试确定的嗅觉不佳是老年人中HF风险增加的适度预测因素.
- 嗅觉障碍特别与HFrEF和心脏功能障碍的亚临床标志物有关.
- 嗅觉评估可能为老年人群中HF风险分层提供一种新的非侵入性方法.
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