表皮竞争决定了抑制Fanconi贫血口腔癌风险的基因疗法潜力

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Hunter L Colegrove1, Raymond J Monnat1,2,3, Alison F Feder1,4

  • 1Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.

PLoS computational biology
|September 10, 2025
PubMed
概括

针对Fanconi贫血 (FA) 的基因疗法在预防头癌方面表现有前途. 计算模型显示,基因纠正细胞需要增殖优势才能有效地在口腔上皮层中传播,指导未来的治疗策略.

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