怀孕和儿童神经发育的高血压障碍:系统性审查和元分析
Jessica A Atkinson1,2, Hannah G Gordon1,2, Stephen Tong1,2
1Perinatal Epidemiology Group, Department of Obstetrics, Gynaecology, and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia.
PLoS medicine
|September 10, 2025
概括
怀孕期间的高血压疾病与儿童的风险增加有关.
科学领域:
- 产周医学 产周医学
- 发育儿科 发育儿科
- 流行病学 流行病学
背景情况:
- 妊娠高血压障碍 (HDP) 可能会增加儿童神经发育不良结果的风险.
- 最近关于这种关联的全面元分析缺乏.
- 现有研究强调需要更新,综合证据.
研究的目的:
- 进行系统审查和元分析.
- 检查HDP与儿童神经发育障碍,智力和教育成果之间的关联.
- 提供当前证据的全面概述.
主要方法:
- 在多个数据库 (MEDLINE,CINAHL,Web of Science,PsycINFO) 进行系统搜索,直到2024年9月.
- 包括观察性研究和随机试验的二次分析.
- 综合结果的元分析,包括自闭症谱系障碍,多动症多动症,智力障碍,全球发育迟缓和智力系数.
主要成果:
- 分析了121项研究,其中包括29,649,667名后代.
- HDP与自闭症谱系障碍 (OR1.65),ADHD (OR1.27),智力障碍 (OR1.77) 和全球发育迟缓 (OR1.77) 的增加未调整的可能性有关.
- 观察到平均智力下降 (MD -2.20);然而,在调整妊娠年龄和出生体重后,一些关联减弱了.
结论:
- HDP可能与后代的不良神经发育和认知结果有关.
- 底层机制需要进一步研究.
- 这些发现确定了那些可能受益于早期干预和支持的儿童.
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