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Updated: Jan 18, 2026

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在活细胞中使用单分子追踪调和EGFR二元化的动态模型.

Kiwook Kim1, Juhee Jang1, Juhyeong Cho1

  • 1Department of Physics and Chemistry, DGIST, Daegu 42988, Republic of Korea.

The journal of physical chemistry. B
|September 10, 2025
PubMed
概括

皮肤表皮生长因子受体 (EGFR) 分解动力学显示负反:更高的表达减少了分解. 还确定了一种二聚体特异性降解途径,揭示了癌症信号传递的复杂调节.

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Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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