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Updated: Jan 18, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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I型干扰素通过调节致病性T助手17细胞中的microRNA-21-FOXO1轴来限制中枢神经系统的自身免疫力

Johnna Francis Varghese1, Mai Fujiwara1, Amrendra K Ajay2

  • 1Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Science translational medicine
|September 10, 2025
PubMed
概括

干扰素-β (IFN-β) 通过减少微RNA-21 (miR-21) 和致病性TH17细胞来治疗多发性硬化症. 抑制miR-21可能有利于对IFN-β治疗无反应者.

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