在社区居住和健康男性中直接测量血清自由的年龄分层参考范围
Joeri Walravens1, Gido Snaterse1, Nick Narinx2
1Department of Endocrinology, Ghent University Hospital; Department of Internal Medicine & Pediatrics, Ghent University, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
这项研究确定了男性测量自由 (mFT) 的参考范围,发现水平随着年龄的增长和更高的BMI而下降. 这些范围有助于对阴道腺缺陷的评估.
科学领域:
- 内分泌学 在内分泌学.
- 安德罗学与人类学
- 临床化学 临床化学
背景情况:
- 直接测量血清自由 (mFT) 对于评估男性阴性双胞胎症至关重要.
- 对mFT的参考范围的有限可用性阻碍了临床应用.
研究的目的:
- 在健康的,居住在社区的成年男性中建立测量自由 (mFT) 的年龄分层参考范围.
- 提供数据,以改善对低阴性恋的临床评估.
主要方法:
- 分析了1202名高加索男性的血清样本.
- 测量自由 (mFT) 通过平衡透析和LC-MS/MS.确定.
- 使用临床和实验室标准研究所指导方针建立的参考范围,定义第2.5个百分点和第97.5个百分点.
主要成果:
- 在健康的非肥胖男性 (18-39岁) 中,mFT的参考范围为184-749 pmol/L.
- 随着年龄的增长,mFT水平下降 (-4.5 pmol/L每年).
- 增加的BMI (30和35 kg/m2) 与22 kg/m2的参考BMI相比,显著减少了mFT.
结论:
- 在迄今为止最大的队列中,为mFT建立了年龄分层的参考范围.
- mFT水平受到年龄和BMI的显著影响.
- 需要进一步研究在临床实践中最佳实施mFT和计算FT.
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