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慢性咳过敏作为神经病变:对管理和新疗法的影响
Kian Fan Chung1,2, Stuart B Mazzone3
11National Heart and Lung Institute, Imperial College London, London, United Kingdom;
Annual review of medicine
|September 10, 2025
概括
慢性咳,通常不耐治疗,源于由于神经炎症导致的咳过敏. 管理正在向个性化,以内型为基础的战略和新疗法发展.
科学领域:
- 肺部病理学 肺部病理学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性咳经常与其他疾病共存,并且可以抵抗针对这些疾病的治疗.
- 咳过敏是一种关键因素,涉及对呼吸道刺激和无害触发物的过度反应.
- 在外围和中心层面的神经炎症和神经病变机制是咳过敏的基础.
研究的目的:
- 审查慢性咳的潜在机制及其耐火性质.
- 概述当前和新兴的慢性咳管理策略.
- 突出转向个性化,基于内型的治疗方法的转变.
主要方法:
- 对慢性咳病理生理学和治疗研究的文献综述.
- 对导致咳过敏的神经炎症和神经病变机制的分析.
- 评估当前的治疗干预措施,包括神经调节剂和语言治疗.
- 探索新的抗咳疗法和基于内型的个性化管理.
主要成果:
- 慢性咳的特点是咳过敏是由神经炎症和神经病变过程驱动的.
- 目前的治疗包括排除相关疾病,其次是神经调节剂和语言治疗.
- 新兴的策略侧重于个性化,内型特异性治疗和新型抗咳剂.
结论:
- 了解咳过敏及其神经生物学基础对于有效的慢性咳管理至关重要.
- 个性化医疗,针对慢性咳的特定内型,代表了治疗的未来.
- 新型抗咳疗法对耐火性慢性咳病例具有前景.
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