轻微的身体异常作为了解性别失调神经发育根源的入口
Yasin Kavla1, Tuncay Sandıkçı2, Şenol Turan1
1Department of Psychiatry, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Türkiye.
Journal of sex & marital therapy
|September 10, 2025
概括
与 cisgender 个体相比,患有性别失调症 (GD) 的个体在轻微的身体异常 (MPA) 中的得分更高. 这表明潜在的生物学因素,包括神经发育方面的因素,可能会导致性别失调症.
科学领域:
- 神经发育科学 神经发育科学
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
背景情况:
- 性别失调 (GD) 的病因是复杂的,涉及生物学,心理社会和潜在的神经发育因素.
- 轻微的身体异常 (MPAs) 是微妙的,通常是先天的,可能表明发育变化的身体特征.
- 在GD和cisgender个体中比较MPA的研究是有限的.
研究的目的:
- 调查和比较MPAs在GD个体 (在出生时被分配为女性[AFAB]和出生时被分配为男性[AMAB]) 与cisgender对照的患病率.
- 通过检查生理发育标志物来探索GD的潜在生物学基础.
主要方法:
- 一项涉及108名GD个体和117名 cisgender对照者的病例控制研究.
- 参与者填写了社会人口统计和临床数据表格.
- 沃尔德罗普MPA尺度被用来量化MPA在不同的身体区域 (总体,面,外围).
主要成果:
- 患有GD (无论是AFAB-GD还是AMAB-GD) 个体的MPA总和面MPA得分与异性对照相比显著更高.
- AFAB-GD个体也显示了远端MPA得分明显高于 cisgender对照.
- 在AFAB-GD和AMAB-GD组之间,外围MPA评分是可比的,两者都相对于异性对照相对较高.
结论:
- 患有GD的个体中MPA得分升高表明早期遗传和环境因素在促进GD的神经发育途径中的潜在作用.
- 研究结果支持这样一个假设,即至少在一小部分个体中,生物机制可能是GD的基础.
- 性取向与性别认同的影响在理解GD病因方面需要进一步考虑.
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