相关实验视频
Updated: Jan 18, 2026

07:42
Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
18.6K
在COVID-19感染后,化学疗法诱导的外周神经病变引起的复发性疼痛 - 一个案例报告
Loc Lam1, Vishal Bansal2, Thomas Chai3
1H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX.
Pain medicine case reports
|September 10, 2025
概括
COVID-19 感染可能会引发复发性化疗诱导的周围神经病变 (rCIPN). 这份病例报告强调了SARS-CoV-2与癌症患者神经病变症状的复发之间的潜在联系.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 众所周知,COVID-19会通过高炎症,高凝血,直接感染或免疫反应引起神经系统并发症.
- 化疗诱导的周围神经病变 (CIPN) 是癌症治疗的常见副作用.
- 在COVID-19感染后的复发性CIPN (rCIPN) 尚未被广泛报道.
研究的目的:
- 报告一种可能由COVID-19感染引发的复发性化疗诱导的外周神经病变 (rCIPN) 的病例.
- 探讨SARS-CoV-2感染与先前存在的神经病变的恶化之间的关联.
主要方法:
- 一个59岁的男性患有直肠腺癌和CIPN的病史的病例报告.
- 记录了患者在感染COVID-19后对rCIPN的经验.
- 比较了SARS-CoV-2感染前后的症状.
主要成果:
- 患者在COVID-19诊断后一周内出现了CIPN症状的复发,包括灼热的疼痛和听觉障碍.
- 复发性神经病变呈现出与他以前的CIPN.类似的分布和质量.
- 在COVID-19感染之前停止化疗后症状得到缓解.
结论:
- COVID-19 感染可能会成为化学疗法诱导的周围神经病变 (rCIPN) 复发的触发因素.
- 这一案例强调了病毒感染和先前存在的神经疾病之间的复杂相互作用.
- 需要进一步的研究来调查COVID-19相关的rCIPN的机制和患病率.
更多相关视频
相关概念视频
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
676
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
676
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
597
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
597
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
606
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
606
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
817
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
817
Peripheral Artery Disease V: Postoperative Nursing Management
379
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
379
Chronic Pancreatitis II: Collaborative Care
317
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
317

