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Updated: Jan 18, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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在RATIONAL研究中仅从瘤综合基因组分析中发现的生殖线发现:错过的机会?

Riziero Esposito Abate1, Alessandro Morabito2, Michele Milella3

  • 1Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy.

JCO precision oncology
|September 10, 2025
PubMed
概括

综合基因组分析 (CGP) 经常识别癌症易感性基因 (CSG) 中的潜在生殖系变异. 然而,大多数患有这些发现的患者并未被转诊接受遗传咨询,这表明瘤学家之间存在知识差距.

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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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