对晚期肝细胞癌的二线疗法和剂量方案的比较有效性和安全性:一个网络元分析
Xinming Lei1, Kejie He1, Yaqin Guo2
1Department of Gastroenterology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang.
European journal of gastroenterology & hepatology
|September 10, 2025
概括
像卡博赞提尼布和潘布罗利祖马布这样的二线疗法显著改善了晚期肝细胞癌 (HCC) 的存活率. 这些治疗方法在疾病控制方面提供了实质性的好处,具有可控的副作用,提高了患者的生活质量.
科学领域:
- 肝病学和瘤学 肝病学和瘤学
- 临床药理学 临床药理学
- 基于证据的医学基于证据的医学.
背景情况:
- 肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
- 有效的二线疗法对于先进的HCC患者至关重要,这些患者对初始治疗没有反应.
研究的目的:
- 进行网络元分析,评估各种高级HCC的二线治疗的安全性和有效性.
- 为了比较包括卡博赞提尼布,潘布罗利祖马布,布里瓦尼布和阿帕蒂尼布在内的治疗方法.
主要方法:
- 26项随机对照试验的网络元分析,涉及10,368名晚期HCC患者.
- 评估总生存率 (OS),无进展生存率 (PFS),客观反应率 (ORR) 和疾病控制率 (DCR).
- 对不良事件 (AE) 的评估,包括3-4级AE.
主要成果:
- 卡博桑提尼布 (60毫克QD) 在OS和PFS中显示出最大的改善.
- 布里瓦尼布 (800 mg OD) 显示出最高的ORR,而阿帕蒂尼布 (750 mg QD) 在DCR中领先.
- 科德里图祖马布提供了最佳的安全性,减少了副作用,而布罗利祖马布显示出良好的有效性,具有可容忍的安全性.
结论:
- 建议卡博赞提尼布和潘布罗利祖马布作为高级HCC的合适的二线选择,平衡生存益处与可管理的不良影响.
- 研究结果支持针对性和免疫疗法的联合使用,以进行先进的HCC管理.
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