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作为双重Mcl-1/COX-2抑制剂的英多尔-伊米达佐衍生物:以设计为导向的合成,分子对接和动力学研究,具有潜在的抗癌和抗炎活性

Phoebe F Lamie1, Peter A Halim2, Ahmed M Sayed3

  • 1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.

Bioorganic chemistry
|September 10, 2025
PubMed
概括

新型的英多尔-伊米达佐衍生物显示出强大的Mcl-1抑制和抗癌活性. 化合物6c,6g和6k有效向癌细胞,并表现出有利的药物特性,提供新的治疗潜力.

关键词:
抗炎药物 抗炎药物 抗炎药物这是一种抗癌药物.Bcl-2家族蛋白质中的一种.动力学模拟的动力学模拟印度尔 - 伊米达佐龙在Mcl-1中.

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