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乳酸作为在炎症条件下氧化应激的治疗调节剂

Surabhi Pandit¹, Mansi Tanwar¹, Anamika Singh¹

¹Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.

Biochemical and biophysical research communications

|September 10, 2025

概括

乳二烯与氧化应激副产品4-hydroxynonenal (4-HNE) 和8-hydroxy-2'-deoxyguanosine (8-OHdG) 结合,作为炎症性疾病的潜在治疗剂.

科学领域:

生物化学生物化学
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

氧化应激和活性氧物种 (ROS) 导致生物分子损伤,导致炎症性疾病.
4-氨 (4-HNE) 和8-基-2'-脱氧氨酸 (8-OHdG) 分别是脂质过氧化和DNA氧化的主要生物标志物.
乳酸具有已知的抗氧化和抗炎性质.

研究的目的:

为了研究乳酸的潜力调节4-HNE和8-OHdG活动.
阐明乳酸和这些氧化应激生物标志物之间的分子相互作用.

主要方法:

分子动力学模拟.分子动力学模拟.
光灭试验. 光灭试验.
表面等离子体共振 (SPR) 分析.

主要成果:

乳二烯对4-HNE和8-OHdG都表现出直接结合,具有微分子亲和力.
结构分析表明,乳酸的域间接口和C-叶片对于结合至关重要.
乳酸有效地隔离脂质衍生的ROS副产品和氧化DNA基.

结论:

乳酸直接与关键的氧化应激生物标志物4-HNE和8-OHdG相互作用.
这些发现阐明了乳酸铁素在氧化还原调节中的机制.
通过减轻氧化应激,乳酸显示出作为治疗炎症状况的治疗剂的潜力.

关键词:

在 4-HNE 中,这是一种8-OHdG.相互作用研究研究.乳酸铁素是乳酸铁素的一种.ROS-副产品的使用情况

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