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自闭症和口腔微生物组:对宿主微生物相互作用和多样性的系统审查
Kausar Sadia Fakhruddin1, Iman Kamal2, Tatia Maglaperidze3
1Faculty of Dentistry, The University of Western Australia, Nedlands, Western Australia, Australia; Faculty of Dentistry, University of Saskatchewan, Saskatchewan, Canada; Center of Excellence in Precision Medicine and Digital Health, Geriatric Dentistry and Special Patients Care International Program, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
International dental journal
|September 10, 2025
概括
口腔微生物组在自闭症谱系障碍 (ASD) 中表现出微妙的变化,特别是影响神经递质通路. 需要进一步的研究来确认联系,并探索ASD的治疗潜力.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
背景情况:
- 自闭症谱系障碍 (ASD) 与口腔微生物组有关,可能通过口腔-肠-大脑轴.
- 这个轴可能会影响ASD和其他神经疾病,如帕金森氏症和阿尔茨海默氏症.
- 了解ASD口腔微生物组的变化对于潜在的诊断和治疗应用至关重要.
研究的目的:
- 系统地审查当前有关ASD口腔微生物组的组成,多样性和功能的知识.
- 探索这些发现的潜在诊断和治疗影响.
主要方法:
- 在Medline,Embase,Scopus和谷歌学者 (2000-2025) 的综合文献搜索.
- 包括同行评审的案例控制和横截面研究.
- 使用纽卡斯尔-太华尺度评估研究质量.
主要成果:
- 包括9项研究 (n=8533);对微生物多样性的发现不一致.
- 功能性分析表明多巴胺和GABA降解的途径发生变化,以及ASD中的lysine代谢.
- 在口腔微生物群和ASD核心症状或外部因素之间没有发现一致的联系.
结论:
- 细微的口腔微生物组变化,特别是与神经递质相关的途径,在ASD患者中观察到.
- 与临床症状的直接关联目前没有证据.
- 未来的多学科和纵向研究对于澄清口腔微生物群在ASD病理生理学和个性化治疗中的作用至关重要.
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