不同生物标本中的金属化物与痴呆症之间的关联:系统性审查和元分析
Xiaojing Zhu1, Jian Ma2, Chen Guo3
1College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, China; Beijing Yanshan Earth Critical Zone National Research Station, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China.
Ecotoxicology and environmental safety
|September 10, 2025
概括
环境中的金属化物会影响大脑健康. 这次审查发现了头发,血清和脑脊液中的特定金属与痴呆风险之间的联系,表明缺陷或过量可能起作用.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 金属化物是无处不在的环境污染物.
- 暴露于金属化物对人类健康构成风险,特别是对中枢神经系统.
- 痴呆症是一种神经退行性综合征,其特征是认知能力下降.
研究的目的:
- 审查和综合当前关于生物样本中的金属化物与痴呆症之间的关联的知识.
- 为了确定与痴呆风险相关的特定金属和生物标本.
主要方法:
- 在PubMed,Embase和Web of Science的系统文献搜索到2025年1月.
- 包括82篇符合资格标准的原创研究文章.
- 随机效应和累积元分析,有偏差风险和证据评估的确定性.
主要成果:
- 与痴呆症的负面关联:头发铁,血清,脑脊液,血液.
- 与痴呆症的积极关联:尿中的铁,血清中的,血清中的.
- //铁缺乏和高/在痴呆病发病的潜在作用.
结论:
- 生物样本中的特定金属 (化物) 含量可能与痴呆症有关.
- 缺少,或铁,以及或的高含量需要进一步调查.
- 由于异质性和局限性,研究结果需要谨慎解释.
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