图布林过乙化驱动HMGB1通过ROS-PARP1轴的核退出,导致罗诺诱导的G2/M停止

Sourav Dutta1, Semanti Chakraborty1, Ayushi Ghosh1

  • 1Institute of Health Sciences, Presidency University, Kolkata, West Bengal, India.

PubMed
概括

罗农药通过诱导细胞循环停止而导致神经退行. 这项研究揭示了一条新的途径,涉及氨酸乙化,线粒体反应性氧物种 (mtROS) 和HMGB1核退出,驱动这种停止.

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