胸前大动脉手术后的性别特定结果
Maria Servito1, Moniruzzaman Moni2, Weiang Yan2
1Division of Cardiac Surgery, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada; Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
The Journal of thoracic and cardiovascular surgery
|September 10, 2025
概括
在胸前大动脉手术后,女性患者的生存率和生活质量 (QoL) 更差. 这项研究强调了手术后结果的显著性别差异,需要进一步研究性别特定的管理策略.
科学领域:
- 心血管外科心血管外科
- 胸前主动脉手术 胸前主动脉手术
- 健康 结果 研究 研究 结果
背景情况:
- 性对生活质量 (QoL) 和胸前大动脉手术后的长期死亡率的影响仍然不太清楚.
- 在胸前大动脉手术后调查与性别相关的结果差异对于改善患者护理至关重要.
研究的目的:
- 确定胸前动脉手术后的生存和生活质量是否存在显著的基于性别的差异.
- 为了比较经过胸前大动脉手术的男性和女性患者的术后结果.
主要方法:
- 从曼尼托巴胸前动脉数据库中确定了1065名接受胸前动脉手术 (2004-2023) 的患者队列.
- 使用逆概率治疗加权来调整基线性别特征差异.
- 评估的结果包括与普通人群相比的生存率,残疾 (中风,长期护理或多次住院) 和出院活着的日子.
主要成果:
- 女性患者 (25%的队列) 年龄较大,并具有较高的并发症得分.
- 在15年后,女性患者的生存率较低 (31%vs. 39%) 和没有残疾 (53%vs. 65%).
- 女性患者在手术后的30,90和180天活着和出院的日数显著下降.
结论:
- 在胸前大动脉手术后,女性患者的生存率和生活质量表现较差.
- 存在很大的差异,女性患者面临更高的残疾和死亡风险 (HR 1.34).
- 进一步的研究是必不可少的,以了解这种差异的原因,并开发胸前动脉疾病的性别特异性管理方法.
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