ACE2通过抑制ROS生产来减轻PEDV诱导的内细胞网膜应激和自
Zhiqiang Li1, Xueqing Chen1, Chang Ma1
1Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, 210095, China.
Microbial pathogenesis
|September 10, 2025
概括
猪流行性腹病毒 (PEDV) 感染引发了内分泌网膜 (ER) 压力和自,这是由活性氧物种 (ROS) 调节的过程. ангиотензин转化酶2 (ACE2) 通过降低 ROS.减轻这种损伤.
科学领域:
- 病毒学 病毒学
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- ангиотензин转化酶2 (ACE2) 在炎症损伤中的作用已知,但其与猪流行性腹病毒 (PEDV) 感染期间的ER压力和自的联系尚不清楚.
- 在猪健康方面,PEDV感染是一个重大问题,造成了相当大的经济损失.
研究的目的:
- 调查PEDV感染,ER压力,自和活性氧物种 (ROS) 之间的联系.
- 探索ACE2在PEDV诱导的ER压力和自中免疫调节作用和分子机制.
主要方法:
- 在细胞中建立了PEDV感染应激损伤模型.
- 在PEDV感染下验证了ER压力,自和ROS之间的关系.
- 调节ACE2表达,以探索其在PEDV诱导的细胞反应中的作用.
主要成果:
- PEDV感染诱导了ER压力,激活了未折叠的蛋白质反应 (UPR).
- 自是由PEDV触发的,由ER压力介导,以促进病毒复制.
- PEDV感染导致ROS积累,ROS作为ER压力和自的上游调节者.
- 通过降低细胞内ROS产量,恢复氧化还原稳定和减轻细胞损伤,ACE2抑制了ER应激和自.
结论:
- PEDV感染诱导ER压力和自,由ROS调节.
- 通过减少ROS,ACE2通过抑制ER压力和自来发挥关键作用,为PEDV诱导的肠损伤提供了潜在的治疗标.
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