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Updated: Jan 18, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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在AID/HAT1中介的JAG1/NOTCH信号的表观遗传原始化驱动了TNBC中瘤微环境的重编程

Junna Jiao1, Zhuangwei Lv2, Kai Zhang2

  • 1School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang Engineering Technology Research Center of immune checkpoint drug for Liver-Intestinal Tumors, Xinxiang Medical University, Xinxiang, Henan 453003, People's Republic of China.

Cellular signalling
|September 10, 2025
PubMed
概括

激活诱导的cytidine去氨酶 (AID) 通过激活NOTCH信号来表观遗传驱动三阴性乳腺癌 (TNBC). 准AID/HAT1-JAG1轴可能会克服治疗耐药性,并增强TNBC中的免疫治疗.

关键词:
激活诱导的cytidine 脱氨酶.表观遗传修饰是一种表观遗传修饰.希斯乙转移酶 1 基因组这是一个NOTCH信号.三重阴性乳腺癌是什么?瘤微环境是一个微环境.

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