相关实验视频
Updated: Jan 18, 2026

12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
10.9K
埃索诺菲尔性颗粒瘤与多炎并发症,并复杂的型皮虫
Chiharu Sugi1, Katsuhiko Ogawa2, Ryota Sugiyama1
1Division of Neurology, Department of Internal Medicine, Nihon University School of Medicine, Itabashi, Tokyo, Japan.
BMJ case reports
|September 10, 2025
概括
本案例报告详细介绍了一例罕见的与多炎 (EGPA) 和状皮炎 (BP) 同时发生的埃索诺菲尔粒状瘤病例. 通过组织分析证实了布鲁斯皮虫的诊断,尽管患者没有外围氨酸友好症.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 类风湿病学 类风湿病学
背景情况:
- 带有多炎 (EGPA) 的埃索诺菲尔粒状瘤和型皮虫 (BP) 是一种具有埃索诺菲尔透的自身免疫疾病.
- 同时发生EGPA和BP的情况非常罕见.
- 在共存病例中出现诊断挑战,特别是关于BP的免疫学确认.
研究的目的:
- 报告一种罕见的EGPA和BP同时存在的病例.
- 为了强调在这种罕见的重叠中诊断的困难.
- 强调组织分析对诊断的重要性.
主要方法:
- 一个有EGPA病史的老年男性的病例介绍.
- 临床评估,包括对麻木和水泡的评估.
- 对抗BP180抗体的免疫学分析.
- 皮肤活检的组织病理学和免疫组织化学检查.
主要成果:
- 患者呈现出暗示高血压的症状,但缺乏外围好色素.
- 在皮肤活检中,通过抗BP180抗体的存在和eosinophilic透证实了BP的诊断.
- 高剂量普雷迪尼索隆治疗改善了水泡和神经病症症状.
结论:
- 这一案例凸显了EGPA和BP之间罕见的重叠.
- 缺少外围乙酸需要直接组织分析来诊断复杂病例的血压.
- 结合本病理学和免疫学评估对于准确的诊断至关重要.
相关概念视频
Peptic Ulcer Disease I: Introduction
745
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
745
Chronic Bowel Disorders: Introduction
748
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
748
Inflammatory Bowel Disease I: Ulcerative Colitis
904
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
904

