重新审视同类半素,维生素B12,叶酸和大动脉疾病之间的关系
Qianlei Lang1, Yu Liu1, Hongwei Zhang1
1Department of Cardiovascular Surgery, West China Hospital, Sichuan University.
International heart journal
|September 10, 2025
概括
这项研究发现,同类氨酸,维生素B12或叶酸水平与大动脉动脉瘤或剖析等大动脉疾病之间没有因果关系. 因此,补充剂可能无法预防这些情况.
科学领域:
- 心血管遗传学 心血管遗传学
- 营养生物化学 营养生物化学
- 流行病学 流行病学
背景情况:
- 观察性研究表明,同类半氨酸 (Hcy),维生素B12,叶酸和大动脉疾病 (AD,TAA,AAA) 之间存在联系.
- 这些因素与大动脉疾病之间的因果关系尚不清楚.
- 在分析中还考虑了大动脉直径.
研究的目的:
- 通过使用孟德尔随机化 (MR) 研究血Hcy,维生素B12和叶酸水平对大动脉疾病的因果作用.
- 评估这些生物标志物的对大动脉直径的影响.
主要方法:
- 采用了两样MR分析,利用Hcy,维生素B12和叶酸的全基因组关联研究中的SNP.
- 使用了各种MR方法,包括逆方差加权,加权中位数和MR-Egger.
- 通过使用科克兰的Q和MR-Egger测试评估异质性和质性;通过离开一个和施泰格过证实了稳定性.
主要成果:
- 核磁共振分析显示,血Hcy,维生素B12或叶酸水平与大动脉疾病 (AD,TAA,AAA) 或大动脉直径之间没有显著的因果关系.
- 统计测试表明没有显著的异质性或质性,证实了研究结果的可靠性.
- 稳定性检查证实了MR结果的稳定性和有效性.
结论:
- 血Hcy,维生素B12和叶酸水平不会因果关系地影响大动脉疾病或大动脉直径的发展.
- 对Hcy升高或维生素B12/叶酸减少的遗传倾向似乎不会导致大动脉疾病.
- 旨在降低Hcy的维生素B12或叶酸补充剂可能不是预防大动脉疾病的有效策略.
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