无症状成年人阶段角度和亚临床动脉样硬化之间的关联:一个大规模的横截面和纵向研究
1Department of Health Promotion Center, the First Affiliated Hospital with Nanjing Medical University.
Journal of atherosclerosis and thrombosis
|September 10, 2025
概括
通过生物电阻分析 (BIA) 测量的相角 (PhA) 与心血管疾病风险有关. 较低的PhA表明亚临床动脉样硬化进展的风险更高,这表明PhA可以监测这种情况.
科学领域:
- 心血管医学 心血管医学
- 生物医学工程 生物医学工程
- 预防性心脏病学 预防性心脏病学
背景情况:
- 来自生物电阻分析 (BIA) 的相角 (PhA) 被认为是心血管疾病 (CVD) 的风险因素.
- 亚临床动脉样硬化症是心血管疾病的前体,在无症状个体中往往没有被检测出来.
- 早期发现和监测亚临床动脉样硬化对于有效的初级预防策略至关重要.
研究的目的:
- 研究PhA与非症状成年人亚临床动脉样硬化的进展之间的关联.
- 确定PhA是否可以作为监测亚临床动脉样硬化的非侵入性标志物.
- 探索PhA和亚临床动脉样硬化标志物之间的关系,包括动脉样硬化 (CAS) 和脚脉冲波速度 (baPWV).
主要方法:
- 截面分析涉及15579名CAS参与者和8228名baPWV参与者,所有参与者都接受了BIA.
- 纵向研究包括2680名参与者进行CAS进展和1775名参与者进行baPWV变化,至少进行了两次测量.
- 亚临床动脉样硬化被评估使用冠状动脉超声波对CAS和baPWV测量.
主要成果:
- 具有CAS或升高baPWV的参与者在横截面研究中表现出明显较低的PhA值 (P<0.001).
- PhA与CAS (调整OR=0.41) 和升高的baPWV (调整OR=0.45) (P<0.001) 独立且反向相关.
- 较高的基线PhA值与事件CAS风险降低相关 (调整HR=0.44) 和与baPWV. baPWV的年度变化有负相关性.
结论:
- 阶段角度 (PhA) 与亚临床动脉样硬化的进展有显著的关联.
- PhA显示出作为监测亚临床动脉样硬化的一种非侵入性生物标志物的潜力.
- 这些发现支持PhA在心血管健康的初级预防设置中的实用性.
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