从空气中生产食物:用氧化细菌精确发酵气体
Margarita Bernal-Cabas1, Karan Kumar2, Owen Terpstra1
1Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, 9747 AG, The Netherlands.
Trends in biotechnology
|September 10, 2025
概括
可持续的粮食生产可以通过使用有氧化细菌 (HOBs) 来将CO2和H2转化为生物质来实现. 这种方法为农业提供了土地和水效的替代方案,具有碳捕获和碳中和食品级蛋白质生产的潜力.
科学领域:
- 生物技术是生物技术.
- 合成生物学 合成生物学
- 可持续的粮食生产可持续的粮食生产
背景情况:
- 六个行星的边界被打破了,需要可持续的粮食生产方法.
- 有氧化氧化细菌 (HOBs) 通过气体发酵将大气中的CO2和H2转化为生物质.
- 目前,该工艺用于单细胞蛋白质生产,提供了与农业无关的供应链,土地和水资源使用最小.
研究的目的:
- 将HOB设计成细胞工厂,用于超出单细胞蛋白质生产的精密发酵.
- 提出一种可扩展的生物工艺蓝图,用于基于气体的发酵.
- 探索使用分泌的重组牛奶蛋白作为HOB应用的案例研究.
主要方法:
- 利用合成生物学,代谢工程,计算建模和生物反应器设计方面的进展.
- 开发可扩展的生物工艺用于基于气体的发酵.
- 使用分泌复合牛奶蛋白生产的案例研究.
主要成果:
- 证明了HOBs在生产超出单细胞蛋白的有价值生物分子方面的潜力.
- 强调了碳中和生产和通过气体发酵捕获碳的可行性.
- 确定了工程HOB精密发酵的关键挑战和机遇.
结论:
- 氧化氧化细菌为可持续的,独立于农业的粮食生产提供了一个有希望的平台.
- 精密发酵的工程HOB对于扩大其应用范围至关重要.
- 气体发酵为实现碳中和生物制造和碳捕获提供了一个可行的途径.
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